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Deseine was born in Paris on July 20, 1749. He was a student of many master sculptors: Augustin Pajou, Edme Dumont, Guillaume II Coustou and Louis-Philippe Mouchy. Deseine left for the Académie de France à Rome in 1781. There he did the customary copies of Antique sculpture and the Deseine expert Lapparent informs us that he filled up a sketchbook, which is now in the Louvre, full of scenes from everyday life. Then on 25 June 1785 Deseine was agré (showing 500 of 3418 characters).