Robert F. "Bo" Brown (1906-1996) was a law student at the University of Pennsylvania in 1930 when he sold two cartoons to the Saturday Evening Post.  The income he received from this sale was impressive when compared to what he could make as a fledgling lawyer, so he decided to take a leave of absence from Penn Law and try his hand at full-time cartooning.  66 years and 33,000 published cartoons later, he was still on leave, and met his last deadline two weeks before his death at 90 in August of 1996.

He always credited his success as a cartoonist to the tireless efforts of his "sales manager" -- his wife, Marge.  Bo Brown's award-winning work was a mirror of himself: droll, witty and sophisticated; seldom laugh-out-loud funny, but with an unerring eye for the human condition.

Source:
Information courtesy of  Allan Dash, went to church with Bo and Marge Brown and knew them well for the last 13 years of his life. The above information is from both published material and personal knowledge.